Article

JOURNAL MENU
Cover
Journal Cover Page

RGUHS Nat. J. Pub. Heal. Sci Vol: 14  Issue: 2 eISSN:  pISSN

Review Article

Emerging Perspectives in Lung Diseases

P.S. Shankar  

Emeritus Professor of Medicine, Rajiv Gandhi University of Health Sciences, Bangalore

Year: 2013, Volume: 3, Issue: 1, Page no. 38-50,
Views: 604, Downloads: 2
Licensing Information:
CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

Autophagy has a prominent role in the biologic pathways involved in chronic lung diseases by affecting immunity, cell proliferation, cell death and disposal of unnecessary proteins. Cell responses against antigens facilitate occurrence of many lung diseases affecting the airways, alveoli and interstitium. Cell death and proliferation are involved in the pathogenesis of lung diseases. A deficiency in autophagy is associated with hyperactivation of inflammation. Induction of autophagy acts as an anti-inflammatory defense. Endothelial dysfunction and pulmonary vascular cell proliferation are associated with pulmonary hypertension. A deficiency or an increase in autophagy activity has a key role in the pathogenesis of different lung diseases. The proper understanding of autophagy involved in lung diseases enables to formulate proper therpy for respiratory diseases.

<p class="MsoNormal"><span lang="EN-US" style="font-size: 12pt; line-height: 115%;">Autophagy has a prominent role in the biologic pathways involved in chronic lung diseases by affecting immunity, cell proliferation, cell death and disposal of unnecessary proteins. Cell responses against antigens facilitate occurrence of many lung diseases affecting the airways, alveoli and interstitium. Cell death and proliferation are involved in the pathogenesis of lung diseases. A deficiency in autophagy is associated with hyperactivation of inflammation. Induction of autophagy acts as an anti-inflammatory defense. Endothelial dysfunction and pulmonary vascular cell proliferation are associated with pulmonary hypertension. A deficiency or an increase in autophagy activity has a key role in the pathogenesis of different lung diseases. The proper understanding of autophagy involved in lung diseases enables to formulate proper therpy for respiratory diseases.</span></p>
Keywords
Autophagy, development of lung diseases, treatment of lung diseases
Downloads
  • 1
    FullTextPDF
Article

none

Supporting File
No Pictures
References

none

We use and utilize cookies and other similar technologies necessary to understand, optimize, and improve visitor's experience in our site. By continuing to use our site you agree to our Cookies, Privacy and Terms of Use Policies.