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RGUHS Nat. J. Pub. Heal. Sci Vol: 14  Issue: 2 eISSN:  pISSN

Original Article

Central Nervous System Involvement and its outcome in Dengue Fever

 Kulkarni ML1* , Kumar Saurabh2 , Sanjana Kalvehalli 3

1 Professor and Head, 2Resident, 3Medical Officer, Department of Paediatrics, JJM Medical College, Davangere

Year: 2012, Volume: 2, Issue: 2, Page no. 74-77,
Views: 596, Downloads: 4
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CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

Background and objective: To study the incidence of CNS manifestations in children with dengue, its spectrum of neurological manifestations and presence of dengue specific IgM antibodies in the CSF.

Method: Prospective study of all serum positive dengue patients (100 cases) admitted to the hospitals attached to J.J.M Medical College, Davangere from January 2009 to September 2010. Children who presented with neurological symptoms were separately grouped and CSF analysis, especially IgM, was done in them.

Result: The neurological incidence in our study was 40%. Seizures were present in 70% of cases and altered sensorium was present in 80% of cases. Papilloedema, and cranial nerve palsies were observed in 30% of cases and meningeal signs were present in 80% of cases. CSF protein was high in 80% of cases and pleocytosis was present in 80% of cases. CSF IgM was positive in 35% of cases. In our study and overall mortality was 4%.

Interpretations and Conclusion: Dengue fever encompasses an expanding clinical spectrum, not just restricted to WHO specified criteria for making a diagnosis other than DHF or DSS. It frequently causes encephalitis probably due to a direct neurotropic effect of dengue virus. 

<p><strong>Background and objective: </strong>To study the incidence of CNS manifestations in children with dengue, its spectrum of neurological manifestations and presence of dengue specific IgM antibodies in the CSF.</p> <p><strong>Method: </strong>Prospective study of all serum positive dengue patients (100 cases) admitted to the hospitals attached to J.J.M Medical College, Davangere from January 2009 to September 2010. Children who presented with neurological symptoms were separately grouped and CSF analysis, especially IgM, was done in them.</p> <p><strong>Result:</strong> The neurological incidence in our study was 40%. Seizures were present in 70% of cases and altered sensorium was present in 80% of cases. Papilloedema, and cranial nerve palsies were observed in 30% of cases and meningeal signs were present in 80% of cases. CSF protein was high in 80% of cases and pleocytosis was present in 80% of cases. CSF IgM was positive in 35% of cases. In our study and overall mortality was 4%.</p> <p><strong>Interpretations and Conclusion: </strong>Dengue fever encompasses an expanding clinical spectrum, not just restricted to WHO specified criteria for making a diagnosis other than DHF or DSS. It frequently causes encephalitis probably due to a direct neurotropic effect of dengue virus.&nbsp;</p>
Keywords
Dengue fever, encephalitis, encephalopathy, neurological manifestations of dengue
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