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RGUHS Nat. J. Pub. Heal. Sci Vol: 14  Issue: 2 eISSN:  pISSN

Original Article

Demographic Profile of Peripheral nerve sheath tumors in aTertiary care centre - A five year study

Malashree1 , Shashikala P2 , Kavita GU3 , Krishnamurthy L4 , Shanthakumar CJ5 , Sathyanarayan MVV6 , L S Patil7 

Postgraduate student , Professor and HOD , Professor , Professor and HOD , Professor , Professor , 1,2,3 4 5,6 7 Department of Pathology , Neurology , Neurosurgery and Surgery , S.S Institute of Medical Sciences and Research Centre, Davangere.

Dr. Kavita GU

Professor, Department of Pathology

S.S Institute of Medical Sciences and Research

Centre, Davangere-577002

Email id: drgukavita@gmail.com

Received Date: 2018-05-19,
Accepted Date: 2018-06-15,
Published Date: 2018-07-31
Year: 2018, Volume: 8, Issue: 3, Page no. 15-18, DOI: 10.26463/rjms.8_3_5
Views: 795, Downloads: 4
Licensing Information:
CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

Background: Peripheral nerve sheath tumors (PNST) are neuroectodermal in origin. More than 90–95% of PNST are benign. Neurofibromas and Schwannomas are the common benign PNSTs. Malignant peripheral nerve sheath tumor(MPNST) may originate de novo or in a plexiform neurofibroma associated with neurofibromatosis, but malignant transformation of a Schwannoma is exceptionally rare.

Methodology: Retrospective cohort study conducted over a period of five years in a tertiary care centre. Demographic details of PNSTcases retrieved from the records were analyzed.

Results: There were 40 specimens with a confirmed diagnosis of PNST from 40 patients who underwent surgery. Male to female ratio was 1.1:1. Most of the PNSTs were encountered in the age group of 21-50 years. Majority of the tumors i.e., 38(95%) were benign. MPNSTconstituted only 5% i.e., 2 cases. Head and neck (32.5%) was the common site for benign PNSTs.

Conclusion: This study concludes that majority of the PNSTs are benign. MPNSTis a rare tumor. 

<p><strong>Background:</strong> Peripheral nerve sheath tumors (PNST) are neuroectodermal in origin. More than 90&ndash;95% of PNST are benign. Neurofibromas and Schwannomas are the common benign PNSTs. Malignant peripheral nerve sheath tumor(MPNST) may originate de novo or in a plexiform neurofibroma associated with neurofibromatosis, but malignant transformation of a Schwannoma is exceptionally rare.</p> <p><strong>Methodology:</strong> Retrospective cohort study conducted over a period of five years in a tertiary care centre. Demographic details of PNSTcases retrieved from the records were analyzed.</p> <p><strong>Results:</strong> There were 40 specimens with a confirmed diagnosis of PNST from 40 patients who underwent surgery. Male to female ratio was 1.1:1. Most of the PNSTs were encountered in the age group of 21-50 years. Majority of the tumors i.e., 38(95%) were benign. MPNSTconstituted only 5% i.e., 2 cases. Head and neck (32.5%) was the common site for benign PNSTs.</p> <p><strong>Conclusion: </strong>This study concludes that majority of the PNSTs are benign. MPNSTis a rare tumor.&nbsp;</p>
Keywords
Peripheral nerve sheath tumor, Schwannoma, Neurofibroma, Malignant peripheral nerve sheath tumor, Neurofibromatosis 1.Key words: inguinal hernia, herniorrrhaphy, hernioplasty,
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