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RGUHS Nat. J. Pub. Heal. Sci Vol No: 10 Issue No: 2  pISSN: 2249-2149

Original Article

Toxicity Studies of Nirgundi (Vitex negundo Linn) Leaf Extracts in Wistar Albino Rats

Satish Pai*,1, K. S Jayashree2, N.B. Shridhar3,

1Dr. Satish Pai, Lecturer, Dept of PG Studies in Dravyaguna, JSS Ayurveda Medical College, Lalitaadripura Road, Mysore 28,

2K. S Jayashree, Former professor & Head, Dept of PG Studies in Dravyaguna, Government Ayurveda Medical College, Dhanvantri Road, Mysore

3N.B. Shridhar, Associate professor, Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore-560024

*Corresponding Author:

Dr. Satish Pai, Lecturer, Dept of PG Studies in Dravyaguna, JSS Ayurveda Medical College, Lalitaadripura Road, Mysore 28,, Email:
Received Date: 2012-09-01,
Accepted Date: 2012-10-01,
Published Date: 2012-10-31
Year: 2012, Volume: 2, Issue: 2, Page no. 39-43,
Views: 266, Downloads: 6
Licensing Information:
CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

Nirgundi. the perennial shrub is used since ages for its Vatahara activity. This plant is also termed to be having Medhya/Smritida activity by nighantukaraS for which Nirgundi is not commonly used. To evaluate its safety, toxicological evaluation was undertaken by using aqueous and alcoholic extracts in various dosages in WIStar albino rats. For assessing the sub-acute toxicity. 28 days repeated dose study was undertaken by using both extracts in 1 , 2, 4 and 8g/kg body weight dosage. No animal died dunng study period but toxicity signs were noticed in higher dosage groups (8g/kg of aqueous extract) and (4 and 8g/kg of alcoholic extract groups). Haematological and biochemical studies showed variations in platelet count, ALT, AST, Serum creatinine and BUN levels in all dosage groups. Histo- pathological study revealed degenerative changes of vital organs (brain, liver, kidneys. spleen, heart and lungs) in higher dosage groups. Spleen and kidney were more affected compared to other Vital organs. Changes were corresponding to the higher dose of the alcoholic extract Present study the mild toxic nature of the plant on spleen. kidney and liver.

<p>Nirgundi. the perennial shrub is used since ages for its Vatahara activity. This plant is also termed to be having Medhya/Smritida activity by nighantukaraS for which Nirgundi is not commonly used. To evaluate its safety, toxicological evaluation was undertaken by using aqueous and alcoholic extracts in various dosages in WIStar albino rats. For assessing the sub-acute toxicity. 28 days repeated dose study was undertaken by using both extracts in 1 , 2, 4 and 8g/kg body weight dosage. No animal died dunng study period but toxicity signs were noticed in higher dosage groups (8g/kg of aqueous extract) and (4 and 8g/kg of alcoholic extract groups). Haematological and biochemical studies showed variations in platelet count, ALT, AST, Serum creatinine and BUN levels in all dosage groups. Histo- pathological study revealed degenerative changes of vital organs (brain, liver, kidneys. spleen, heart and lungs) in higher dosage groups. Spleen and kidney were more affected compared to other Vital organs. Changes were corresponding to the higher dose of the alcoholic extract Present study the mild toxic nature of the plant on spleen. kidney and liver.</p>
Keywords
Vitex negundo, Rat, Aqueous extract,Alcoholicextract, Toxicity, Haematology, Biochemistry, Histopathology
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