Background: Migraine, a chronic neurological disorder is characterized by moderate to severe headache episodes. Sumatriptan succinate, an FDA-approved treatment for migraine in adults, has demonstrated efficacy. Meanwhile, Feverfew, with a traditional application for fever and migraine, provides herbal avenue for therapeutic intervention. This study seeks for the synergistic effect of both drugs by formulating orodispersible tablets (ODT) with a blend of synthetic and herbal drugs, employing superdisintegrants and the sublimation technique. Methods: The ODTs were crafted via direct compression method using superdisintegrants croscarmellose sodium, crospovidone, and sodium starch glycolate at varying concentrations (2%, 4%, and 6%). Kyron T114 was employed to mask the bitter taste of Sumatriptan succinate. The optimized formulation, selected based on the least disintegration time (DT), underwent reformulation using sublimating agents (camphor, thymol, or menthol) at varying concentrations (1%, 2%, 3%) to further minimize DT. Results: Evaluation of pre- and post-compression parameters, including weight variation, hardness, friability, DT, and in-vitro drug release, met specified limits. The formulation featuring 6% crospovidone and 2% menthol exhibited a DT of 14 seconds and achieved drug release >90% within five minutes; thus was identified as the optimized formulation. Accelerated stability studies and kinetic modelling were conducted for this formulation. Conclusion: The synergistic combination of synthetic and herbal components in the optimized ODT offers a novel therapeutic approach for migraine management, emphasizing both patient compliance and treatment effectiveness.

Background: Periodontal disease affects individuals of all ages, ethnicities, genders as well as socioeconomic backgrounds and is acknowledged as a serious public health issue globally. Objectives: The development and formulation of herbal remedies is the primary goal of this research work. Our goal in conducting this survey was to learn more about people's experiences with dental care and products, as well as their requirements, preferences, and problems in this regard. By gathering this data, we could gain valuable insights into enhancing dental care practices and products to promote better oral health. Methods: The current study conducted an initial survey via Google Forms. Based on the survey, it was decided to formulate and develop an oral disease therapy product, such as a dental gel infused with oils of clove, neem, peppermint, camphor, and Triphala extract. Several tests to determine the acid value, ester value, saponification value, and specific gravity of clove oil and neem oil were conducted. The formulated emulgel was evaluated using the tests, such as spreadability, extrudability, pH, and viscosity. Results: The survey's results showed a tendency or preference for the application of herbal remedies in dental treatment. The emulgel formulations demonstrated good physicochemical qualities and stability. Conclusion: Based on the current study results, it can be concluded that clove and neem oil can be successfully incorporated into the gel.